Endocrine Abstracts

In vitro studies suggest that glucocorticoids (GC) long-term exposure downregulates SSTR2 but not SSTR5 expression in human and mouse ACTH-secreting tumor cells (AtT20), limiting the efficacy of octreotide (OCT), a somatostatin-receptor ligand with high affinity for SSTR2, in the treatment of Cushing’s disease (CD). In AtT20, dexamethasone treatment increased miR-375 expression, whose analysis revealed a seed-sequence for SSTR2, supporting the hypothesis that exc...

Introduction: Neuroendocrine neoplasms (NEN) represent a group of rare neoplasms characterized by wide heterogeneity in terms of biological characteristics and clinical behavior. Despite their increasing relevance in the oncology field, health-related quality of life (HRQoL) and sexual function remain poorly investigated.Aim: To investigate sexual function in patients affected by NEN; to evaluate the impact of clinical severity (presence or absence of me...

Life-long glucocorticoid (GC) treatment is needed in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, to replace GC deficiency and to control androgens excess. Multiple daily immediate-release-hydrocortisone (IR-HC), characterized by GC overexposure, peaks and troughs, is frequently associated with a suboptimal androgen control, due to ACTH overnight increase. Once daily dual-release-HC (DR-HC), approved for adrenal insufficiency and, despit...

Acquired resistance has limited the use of systemic molecular therapy in the management of hepatocellular carcinoma (HCC). Immunotherapy, alone and in combination with systemic molecular therapy, is now the first-line standard of care for HCC. The current in vitro study aims at investigating PER2 role in the HCC aggressiveness and drug resistance acquisition. Parental PLC/PRF/5, PLC/PRF/5 resistant to Everolimus (EveR) and to Sorafenib (SorR) cell lines were used. To evaluate ...

Context: Prolactin (PRL) exerts a crucial role in the regulation of mammalian reproduction and in the promotion of lactation as response to the suckling reflex. Beyond this, it directly modulates gluco-insulinemic metabolism.ObjectiveTo dissect glucose metabolism during and after pregnancy in patients with chronic hyperprolactinemia (CTPE).MethodsThis longitudinal study included 52 reproductive aged women with CTPE due to pituitary adenomas (43 microadenomas, 9 macroadenomas),...

Purpose: The present study aimed at investigating the morphology and function of reproductive system in women with hyperprolactinemia (HPRL) receiving chronic treatment with cabergoline (CAB)Methods: Twenty-three women(aged 34.21±10.09 yrs) with HPRL, including 17 with microprolactinoma, 3 with macroprolactinoma and 3 with iatrogenic HPRL, entered the study. All patients were well-controlled with CAB treatment (medium dose 0.46±0.45 mg/week). In po...

Rationale: The gluco-metabolic changes during pregnancy significantly impact women’s sexual behavior. This study aimed to define the relationship between metabolic health and sexual function, along with human circadian rhythms and sleep quality during pregnancy.Methods: This study included 57 pregnant women (14 evaluated at first trimester, G1; 18 at second trimester, G2, and 25 at third trimester, G3). Among groups, no difference between age, gesta...

The potential independent role of growth hormone (GH) excess in sexual dysfunction of acromegalic male patients is poorly characterized. The aim of the current study was to evaluate the sexual function, in adult males with acromegaly, stratifying the cohort in “uncontrolled” and “controlled” disease. Data were retrieved from GONADIS, a national registry on gonadal status and reproductive and psycho-sexual function in patients affected by pituitary and adren...

The current study evaluated the impact of metabolic and hormonal alterations on sexual and psychological function in women with Polycystic Ovary Syndrome (PCOS). Fifty consecutive women aged 24.16±5.97 years with a diagnosis of PCOS were recruited; metabolic and hormonal parameters were measured and questionnaires related to sexual function (Female Sexual Function Index-FSFI) and psychological traits (Middlesex Hospital Questionnaire-MHQ, Body Uneasiness Test A and B-BUT A ...

Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration. Cadmium (Cd) is consistently shown to affect male reproductive function by multiple mechanisms, mostly elucidated in experimental models. The aim of the current single-center, observational, cross-sectional cohort study was to evaluate the prevalence of testis morphostructural alterations in a large cohort of men liv...